*000      ap
*00141884
*100  $aSelbæk-Tungevåg, Selma
*245  $aInsomnia and risk of dementia in a large population-based study with 11-year follow-up: The HUNT study$cSelma Selbæk-Tungevåg, Geir Selbæk, Bjørn Heine Strand, Christian Myrstad, Gill Livingston, Stian Lydersen, Sverre Bergh, Linda Ernstsen
*260  $c2023
*300  $ahttps://doi.org/10.1111/jsr.13820
*440  $aJournal of Sleep Research
*505  $aSummary: Despite evidence suggesting that insomnia is associated with the risk of dementia and cognitive dysfunction, studies have shown mixed results. Dementia has a long prodromal phase, and studies with long follow-up are required to avoid reverse causality. In our 11-year follow-up study, we assessed whether probable insomnia disorder (PID) based on diagnostic criteria, and insomnia symptoms were associated with risk of all-cause dementia, Alzheimer's disease (AD) and cognition, measured with the Montreal Cognitive Assessment scale. We also examined if Apolipoprotein E genotype modified any associations with dementia through interaction. We analysed data from 7492 participants in the Norwegian Trøndelag Health Study. PID was not associated with all-cause dementia (odds ratio = 1.03, 95% confidence interval = 0.74–1.43), AD (odds ratio = 1.07, 95% confidence interval = 0.71–1.60) or Montreal Cognitive Assessment score (regression coefficient = 0.37, 95% confidence interval = −0.06 to 0.80). The insomnia symptom “difficulties maintaining sleep” was associated with a lower risk of all-cause dementia (odds ratio = 0.81, 95% confidence interval = 0.67–0.98), AD (odds ratio = 0.73, 95% confidence interval = 0.57–0.93), and better Montreal Cognitive Assessment score, mean 0.40 units (95% confidence interval = 0.15–0.64). No interaction with Apolipoprotein E genotype was found. PID and insomnia symptoms did not increase the risk of dementia in our study. More research with longer follow-up is needed, and future studies should explore if the associations to dementia risk vary across insomnia subtypes.
*650  $aSøvn
*650  $aSøvnproblemer
*650  $aDemens
*650  $aRisikofaktorer
*650  $aHUNT
*700  $aSelbæk, Geir
*700  $aStrand, Bjørn Heine
*700  $aMyrstad, Christian
*700  $aLivingston, Gill
*700  $aLydersen, Stian
*700  $aBergh, Sverre
*700  $aErnstsen, Linda
*856  $uhttps://doi.org/10.1111/jsr.13820
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